After spending 15 years as an exclusive online service, PayPal is aiming to reach an offline audience ten times bigger through its partnership with Discover Financial Services.
The new endeavour aims to claim one million extra stores in the United States as clients by the end of 2013.
Discover is connecting PayPal with 1.5 million of its own customers with negotiations underway.
Groups already opting for in-store PayPal offers include Total System Services Inc and Global Payments Inc, Reuters reported.
In addition, a variety of stores will also accept PayPal payments, including fast food franchise Burger King, cosmetic brand Sephora and gadget retailer Brookstone.
American general store Wal-Mart is however refusing to allow PayPal payment options due to administrative reasons.
Randy Hargrove, Wal-Mart spokesperson, said: "The added complexity at the point of sale does not justify acceptance of PayPal."